Senior Bioinformatician - Juno Project

Salary in the region of £36,737- £44,451 (dependent on experience) plus excellent benefits

Fixed term for 3 years

We are looking to recruit a Senior Bioinformatician to join a major international research project, funded by the Bill and Melinda Gates Foundation, that aims to sequence and analyse the genomes of a large collection of Streptococcus agalactiae samples to inform global disease prevention strategies.

We are seeking to appoint a talented and motivated individual with a strong interest in the application of genomic data to study pathogen biology and evolution. Ideally you would have an experience in statistical genetics, microbial genomics, computational biology, or a related discipline, with a demonstrated expertise in applying a broad range of genomic analysis approaches to complex datasets to infer biological insights. You will be responsible for bioinformatic analysis of large genomic datasets using existing tools/skills and novel data analysis approaches. This post offers an exciting opportunity to join the leaders of a global research consortium and to collaborate with a number of international project partners to deliver key data analysis outputs and scientific papers.

This 3-year post will be based in the Genomics of Pneumonia and Meningitis team, part of the Parasites and Microbes Programme at the Wellcome Sanger Institute. The Institute has a world class record of pioneering the use of large-scale genomic data analysis to understand pathogen biology, epidemiology and evolution. You will join a team that is engaged in many exciting research topics such as person-to-person transmission of pathogens, global spread of high-risk clones and evolution of resistance to antibiotics and vaccines. Our studies are supported by genomic, clinical and epidemiological data for thousands of samples providing opportunity for well-powered analyses. We are a multi-disciplinary team that combines the expertise of microbiologists, mathematicians, bioinformaticians and software developers. Here's a selection of recent and past papers that gives an overview of our interests:

  • Lees et al., (2019) Joint sequencing of human and pathogen genomes reveals the genetics of pneumococcal meningitis Nature Communications
  • Gladstone et al., (2019) International genomic definition of pneumococcal lineages, to contextualise disease, antibiotic resistance and vaccine impact. EBioMedicine
  • Lees et al., (2019) Fast and flexible bacterial genomic epidemiology with PopPUNK. Genome Research
  • Lo et al., (2018) Global distribution of invasive serotype 35D Streptococcus pneumoniae isolates following introduction of 13-valent pneumococcal conjugate vaccine. Journal of Clinical Microbiology
  • Lees et al., (2017) Genome-wide identification of lineage and locus specific variation associated with pneumococcal carriage duration. eLife
  • Chaguza et al., (2016) Recombination is Streptococcus pneumoniae lineages increase with carriage duration and size of the polysaccharide capsule. mBio
  • Chewapreecha et al., (2014) Dense genomic sampling identifies highways of pneumococcal recombination. Nature Genetics

For informal enquiries about the post please contact Stephen Bentley ()

Essential Skills

  • PhD in statistical genetics, microbial genomics, computational biology, or a related discipline
  • Demonstrated experience analysing genomic data
  • Excellent communication skills, ability to interact with a multi-disciplinary team to develop and maintain good working relationships
  • Keen to learn and share scientific ideas
  • Attention to detail
  • Problem-solving and data skills
  • Proven track record of publishing papers in reviewed journals

Ideal Skills

  • Demonstrated experience working with large microbial genomic datasets
  • Demonstrated experience in developing novel approaches to analysis of large genomic datasets
  • Demonstrated experience working with international collaborators
  • Excellent quantitative skills and statistical knowledge

Other information

The Wellcome Sanger Institute is a charitably funded research centre and committed to training the next generation of genome scientists. Focused on understanding the role of genetics in health and disease and a world leader in the genomic revolution, our mission is to use genome sequences to advance understanding of human and pathogen biology in order to improve human health. We aim to provide results that can be translated into diagnostics, treatments or therapies that reduce global health burdens. Our science is large-scale and organised into Programmes, led by our Faculty who conceive and deliver our science, and supported by our Scientific Operations teams responsible for all data production pipelines at the Institute.

Our Campus: Set over 125 acres, the stunning and dynamic Wellcome Genome Campus is the biggest aggregate concentration of people in the world working on the common theme of Genomes and BioData. It brings together a diverse and exceptional scientific community, committed to delivering life-changing science with the reach, scale and imagination to pursue some of humanity's greatest challenges.

Our Benefits: Our employees have access to a comprehensive range of benefits and facilities including:

  • Group Defined Contribution Pension Scheme and Life Assurance
  • Group Income Protection
  • Private Health Insurance
  • 25 days annual leave, increasing by one day a year to a maximum of 30
  • Family friendly environment including options for flexible and part-time working, a childcare voucher scheme, Campus Nursery and Summer holiday club
  • Two days paid Employee Volunteering Leave a year
  • Employee Discount Scheme
  • Campus Gym, tennis courts, cricket pitch and sports hall plus a range of dining facilities
  • Active Campus Sports and Social Club
  • Free Campus Bus Service

Genome Research Limited hold an Athena SWAN Bronze Award and will consider all individuals without discrimination and are committed to creating an inclusive environment for all employees, where everyone can thrive.

Please include a covering letter and CV with your application. Closing date for applications: 24th June 2019

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The Wellcome Trust Sanger Institute
Contract Type
Expiry Date
26/06/2019 08:59:00
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